Motif Neurotech, a Houston-based neurotechnology company, today announced their selection by UK’s Advanced Research and Invention Agency (ARIA) for multimillion dollar award to support Motif’s development of a therapeutic brain-computer interface (BCI) technology to treat cognitive and psychiatric conditions. The award will fund development of a network of neural devices designed to monitor and regulate mental and cognitive states without brain surgery. The award is part of ARIA’s Precision Neurotechnologies program, led by program director Jacques Carolan.

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2024 rendering of Motif Neurotech's Digitally Programmable Over-brain Therapeutic (DOT). (Photo: Business Wire)

“We are thrilled to have been to be a part of this important program,” said Jacob Robinson, CEO of Motif Neurotech. “This funding will allow us to accelerate our efforts to develop a general-purpose platform capable of accurately monitoring and regulating mental and cognitive states. The brain is an electrical organ. We believe that mental and cognitive disorders will be best treated by interacting with the brain in its native language.”

The technology planned with this funding could have a profound impact on the treatment of cognitive, neurological, and psychiatric conditions by helping to regulate brain states associated with mood, attention, and sleep. Part of this award will focus on making the technology more accessible to patients by designing implantation to be simple, rapid, and low risk. This work will also focus on improving the specificity of brain stimulation by targeting specific cell types, which could lead to more effective treatments with fewer side effects.

The interface consists of a network of millimeter-sized wireless implants placed in the skull during a 20-minute procedure and designed to be cosmetically invisible. Without contacting the brain, each device will provide cell-type specific stimulation and electrical recording. Arrays like these could span the entire cortical surface, enabling regulation of brain-wide circuits in a way that meets the needs of each patient.

Motif Neurotech will collaborate with research partners under this grant to develop the technology. MintNeuro, a UK startup, will help develop custom integrated circuits that will help to miniaturize the implants. Kaiyuan Yang, an associate professor of Electrical and Computer Engineering department at Rice University will help design circuits for efficient wireless data and power transfer. The Robinson Lab at Rice University will support system integration and testing. Valentin Dragoi, a professor of electrical and computer engineering at Rice, the Rosemary and Daniel J. Harrison III Presidential Distinguished Chair in Neuroprosthetics at Houston Methodist and professor of neuroscience at Weill Cornell Medical College will lead the preclinical animal studies.

The ARIA award is a major milestone for Motif Neurotech and a significant vote of confidence in the company’s technology. This funding will help Motif advance its mission of creating neural devices to help everyone with mental or cognitive disorders live a better life.

About Motif Neurotech

Motif Neurotech is a privately held neurotechnology company developing miniature neural devices to help people regulate their mood, attention, and cognition. The company’s mission is to help everyone live a better life with neural devices. Motif’s first product the DOT, is in clinical development and is designed to address treatment resistant depression (TRD), a condition affecting millions of people in the US and tens of millions of people worldwide.

About ARIA

ARIA is an R&D funding agency created to unlock technological breakthroughs that benefit everyone. Created by an Act of Parliament and sponsored by the Department for Science, Innovation and Technology, we fund teams of scientists and engineers to pursue research at the edge of what is scientifically and technologically possible.

View source version on businesswire.com: https://www.businesswire.com/news/home/20250120600396/en/

Joslyn Williams, joslyn@motifneuro.tech

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