STOCKHOLM, Jan. 31, 2024 /PRNewswire/ -- Sobi® will present new data at the 17th European Association of Haemophilia and Allied Disorders (EAHAD) conference in Frankfurt from 6-9 February 2024. The studies that will be presented support Sobi's ongoing commitment to evolving treatment options for people with haemophilia.

"We are proud to showcase new data at EAHAD 2024, including several new data sets that add to the substantial evidence supporting the use of efanesoctocog alfa in children and highlighting improvements in patient-reported outcomes. Our hope is that these advancements will open new possibilities for people with haemophilia," said Lydia Abad-Franch, Head of R&D and Chief Medical Officer at Sobi. "We will also present further data reinforcing the comprehensive evidence supporting the safety and effectiveness of Elocta® and Alprolix®. Sobi's involvement at EAHAD underscores our continued dedication to advancing knowledge and raising standards of care."

Key Sobi data to be presented at EAHAD 2024


     Efanesoctocog Alfa - Joint Sobi/Sanofi             Effective protection with once-weekly efanesoctocog alfa in children: Secondary analyses of                        Oral presentation
                                                          pharmacokinetics and bleeds from the XTEND-Kids trial                                                              number: OR12



     Efanesoctocog Alfa - Joint Sobi/Sanofi           
     Efanesoctocog Alfa Prophylaxis Outcomes in European Patients From the XTEND-1 Trial                                Poster presentation
                                                                                                                                                                             number:
                                                                                                                                                        PO113



     Efanesoctocog Alfa - Joint Sobi/Sanofi           
     Clinical overview of perioperative outcomes from the XTEND-Kids study                                              Poster presentation
                                                                                                                                                                             number:

                                                                                                                                                        
            PO050



     Efanesoctocog Alfa - Joint Sobi/Sanofi             Treatment Preferences in Previously Treated Patients with Haemophilia A: Phase 3 XTEND-1                           Poster presentation
                                                          Study of Efanesoctocog Alfa                                                                                        number:
                                                                                                                                                        PO123



     Efanesoctocog Alfa - Joint Sobi/Sanofi             Quality of Life in Children with Haemophilia A: Phase 3 XTEND-Kids Study of Efanesoctocog                          Poster presentation
                                                          Alfa                                                                                                               number:
                                                                                                                                                         PO134



     Efanesoctocog Alfa - Joint Sobi/Sanofi             Systematic literature review to evaluate haemophilia A therapies in paediatric patients                            Poster presentation
                                                          without inhibitors                                                                                                 number:
                                                                                                                                                         PO184



     locta(R)/Eloctate(R) (efmoroctocog alfa) - Sobi    Immune Tolerance Induction with a Recombinant Factor VIII Fc in Haemophilia A: Final Data from                     Poster presentation
                                                          a Chart Review Study                                                                                               number:
                                                                                                                                                          PO103



     Elocta(R)/Eloctate(R) (efmoroctocog alfa) - Sobi   Real-world effectiveness and safety of a recombinant Factor VIII Fc in patients with                               Poster presentation
                                                          haemophilia A by age groups: Pooled analysis (A-SURE/PREVENT)                                                      number:
                                                                                                                                                        PO085



     Elocta(R)/Eloctate(R) (efmoroctocog alfa) - Sobi   Real-world effectiveness and safety of a recombinant Factor VIII Fc in patients with                               Poster presentation
                                                          haemophilia A by disease severity: Pooled analysis (A-SURE/PREVENT)                                                number:
                                                                                                                                                           PO099



     Alprolix(R) (eftrenonacog alfa)                    Real-World Effectiveness and Usage of Recombinant Factor IX Fc: Secondary Paediatric Analysis                      Poster presentation
                                                          from the 24-Month French, Prospective, Non-Interventional B-SURE Study                                             number:
                                 - Sobi                                                                                                                    PO068



     Alprolix(R) (eftrenonacog alfa)                    Interim Analysis of Real-World Effectiveness and Usage of Recombinant Factor IX Fc for                             Poster presentation
                                                          Surgical Haemostasis from the 24-Month Prospective, Non-Interventional B-MORE Study                                number:
                                 - Sobi                                                                                                                   PO043



     Alprolix(R) (eftrenonacog alfa)                    Real-World Effectiveness and Usage of Recombinant Factor IX Fc: Interim Analysis in                                Poster presentation
                                                          Paediatric Patients from the 24-Month, Prospective, Non-Interventional B-MORE Study                                number:
                                 - Sobi                                                                                                                    PO127



     Haemophilia                                        Physical Activity Awareness Among People with Haemophilia and their Caregivers in Central                          Poster presentation
                                                          Europe                                                                                                             number:
                                                                                                                                                        PO299
                                                                                                                                                        Session date and time:

                                                                                                                                                                 6 February 2024, from
                                                                                                                                                                  12:00 to 20:30

All presentations can be accessed via the official EAHAD 2024 website.

About efanesoctocog alfa

Efanesoctocog alfa [Antihemophilic Factor (Recombinant), Fc-VWF-XTEN Fusion Protein] (formerly BIVV001) is a new class and investigational recombinant factor VIII therapy with the potential to deliver near-normal factor activity levels for a significant parts of the week, improving bleed protection in a once-weekly dose for people with haemophilia A. Efanesoctocog alfa builds on the innovative Fc fusion technology by adding a region of von Willebrand factor and XTEN® polypeptides to extend its time in circulation. It is the only therapy that has been shown to break through the von Willebrand factor ceiling, which imposes a half-life limitation on current factor VIII therapies. It is approved and marketed as ALTUVIIIO™ [Antihemophilic Factor (Recombinant), Fc-VWF-XTEN Fusion Protein-ehtl] by Sanofi in the United States, Japan and Taiwan. The European Commission granted Orphan Drug designation in June 2019, and the European Medicines Agency accepted the Marketing Authorisation Application (MAA) for efanesoctocog alfa in May 2023.

About Elocta®/Eloctate®

Elocta®/Eloctate® (efmoroctocog alfa) is a recombinant clotting factor therapy developed for haemophilia A using Fc fusion technology to prolong circulation in the body. It is engineered by fusing factor VIII to the Fc portion of immunoglobulin G subclass 1, or IgG1 (a protein commonly found in the body), enabling Elocta to use a naturally occurring pathway to extend the time the therapy remains in the body (half-life). Elocta is manufactured using a human cell line in an environment free of animal and human additives. Elocta is approved and marketed by Sobi for the treatment of haemophilia A in the EU, the UK, Iceland, Kuwait, Liechtenstein, Norway, Saudi Arabia and Switzerland. It is approved and marketed as Eloctate® (Antihemophilic Factor [Recombinant], Fc Fusion Protein) by Sanofi in the United States, Canada, Japan, Australia, New Zealand and other countries, where Sanofi has the marketing rights.

About Alprolix®

Alprolix® (eftrenonacog alfa) is a recombinant clotting factor therapy developed for haemophilia B using Fc fusion technology to prolong circulation in the body. It is engineered by fusing factor IX to the Fc portion of immunoglobulin G subclass 1, or IgG1 (a protein commonly found in the body), enabling Alprolix to use a naturally occurring pathway to extend the time the therapy remains in the body (half-life). Alprolix is manufactured using a human cell line in an environment free of animal and human additives. Alprolix is approved and marketed by Sobi for the treatment of haemophilia B in the EU, the UK, Iceland, Kuwait, Liechtenstein, Norway, Saudi Arabia and Switzerland. It is also approved in the United States, Canada, Japan, Australia, New Zealand and other countries where Sanofi has the marketing rights.

About the Sanofi and Sobi collaboration

Sobi and Sanofi collaborate on the development and commercialisation of Alprolix® and Elocta®/Eloctate®. The companies also collaborate on the development and commercialisation of efanesoctocog alfa or ALTUVIIIO™ in the US. Sobi has final development and commercialisation rights in the Sobi territory (essentially Europe, North Africa, Russia, and most Middle Eastern markets). Sanofi has final development and commercialisation rights in North America and all other regions in the world excluding the Sobi territory.

Sobi®

Sobi® is a specialised international biopharmaceutical company transforming the lives of people with rare and debilitating diseases. Providing reliable access to innovative medicines in the areas of haematology, immunology and specialty care, Sobi has approximately 1,800 employees across Europe, North America, the Middle East, Asia and Australia. In 2022, revenue amounted to SEK 18.8 billion. Sobi's share (STO:SOBI) is listed on Nasdaq Stockholm. More about Sobi at sobi.com, LinkedIn and YouTube.

Contacts

For details on how to contact the Sobi Investor Relations Team, please click here. For Sobi Media contacts, click here.

The following files are available for download:


     
     https://mb.cision.com/Main/14266/3918272/2571846.pdf Sobi to present new data at EAHAD
                                                              2024

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